State police say a passenger vehicle went out of control on a snowpack-covered highway in the northern Lower Peninsula and slid in front on an oncoming semi, killing at least two people.
Sergeant Tony Harrington says the crash happened about 1 p.m. Wednesday on M-32 near Johannesburg in Otsego County. He says details on the crash and the victims' identities weren't yet known.
Earlier weather-related crashes have claimed at least four lives in the state, and a man in Paw Paw died of a heart attack while clearing snow.
Dangerously cold wind chill temperatures are persisting in Michigan, prompting officials to keep many schools closed.
The temperature hit minus 6 early Wednesday in Three Rivers in the southwestern Lower Peninsula. Statewide temperatures were mainly in the teens Wednesday afternoon.